Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies

Abstract excerpt

Human V H single domains represent a promising class of antibody fragments with applications as therapeutic modalities. Unfortunately, isolated human V H domains also generally display poor biophysical properties and a propensity to aggregate. This has encouraged the development of non-human antibody domains as alternative means of antigen recognition and, in particular, camelid (V H H) domains. Naturally devoid...

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