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Structure- and sequence-based design of synthetic single-domain antibody libraries

1 Jan 2020

Abstract excerpt

Single-domain antibody fragments known as VHH have emerged in the pharmaceutical industry as useful biotherapeutics. These molecules, which are naturally produced by camelids, share the characteristics of high affinity and specificity with traditional human immunoglobulins, while consisting of only a single heavy chain. Currently, the most common method for generating VHH is via animal immunization, which can be...

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Glycosylation and Glycoproteins Research
Monoclonal and Polyclonal Antibodies Research
Protein purification and stability

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33341882
DOI: 10.1093/protein/gzaa028

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