Yeast-based production platform for potent and stable heavy chain-only antibodies

Abstract excerpt

Monoclonal antibodies are the leading drug of the biopharmaceutical market because of their high specificity and tolerability, but the current CHO-based manufacturing platform remains expensive and time-consuming leading to limited accessibility, especially in the case of diseases with high incidence and pandemics. Therefore, there is an urgent need for an alternative production system. In this study, we present a...

Topics

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• Antibodies
• Camelids, New World
• Complementarity Determining Regions
• Immunoglobulin Heavy Chains
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• Transgenic Plants and Applications
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

c043812a-8cb0-5613-a670-3dc52d3df37b

DOI

10.1101/2024.03.04.580093