Article

Nuclear aging in polyglutamine-induced neurodegeneration

2023-06-11

Abstract excerpt

Machado-Joseph disease (MJD) is an autosomal dominantly-inherited neurodegenerative disorder characterized by an over-repetition of the CAG trinucleotide of the ATXN3 gene, conferring a toxic gain-of-function to the resulting ataxin-3 protein. Despite the significant advances produced over the last years, the molecular mechanisms involved in MJD are still unclear and no treatment able to modify the disease progre...

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Literature Corpus work: 34d9b925-930d-5457-9485-208d1f29868d
DOI: 10.1101/2023.06.09.544056

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