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Article

The 'golden age' of DNA methylation in neurodegenerative diseases.

Clinical chemistry and laboratory medicine - 1 Mar 2013

Fuso Andrea

Abstract excerpt

DNA methylation reactions are regulated, in the first instance, by enzymes and the intermediates that constitute the 'so called' one-carbon metabolism. This is a complex biochemical pathway, also known as the homocysteine cycle, regulated by the presence of B vitamins (folate, B6, B12) and choline, among other metabolites. One of the intermediates of this metabolism is S-adenosylmethionine, which represent the...

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PMID: 23183753
DOI: 10.1515/cclm-2012-0618

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