Article

Evolutionary Conservation and Functional Constraint of TP53 Mutation Hotspots Across Mammalian Species

2026-04-03

Abstract excerpt

<title>Abstract</title> <p>The tumour suppressor protein TP53 is essential for preserving genomic integrity and is among the most frequently mutated genes in human cancers. Mutations in TP53 show a non-uniform distribution and are concentrated at specific residues, commonly referred to as mutation hotspots. Although these positions are well characterised in clinical studies, their evolutionary behaviour across sp...

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Literature Corpus work: 25aaf237-2384-55c9-9b4b-0cd85d0b86d6
DOI: 10.21203/rs.3.rs-9299199/v1

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