Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

Oncogene - 7 Jan 1999

Walker D R, Bond J P, Tarone R E, Harris C C, Makalowski W, Boguski M S, Greenblatt M S

Abstract excerpt

Missense mutations in p53 frequently occur at 'hotspot' amino acids which are highly conserved and represent regions of structural or functional importance. Using the p53 mutation database and the p53 DNA sequences for 11 species, we more precisely defined the relationships among conservation, mutation frequency and protein structure. We aligned the p53 sequences codon-by-codon and determined the degree of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Conformation

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 9926936
DOI: 10.1038/sj.onc.1202298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.PMID 9926936Read ↗

Evolutionary Conservation and Functional Constraint of TP53 Mutation Hotspots Across Mammalian SpeciesSemantic proximity Read ↗

Mutation hotspots in the p53 gene in tumors of different origin: correlation with evolutionary conservation and signs of positive selection.Semantic proximity Read ↗

Mutational Hotspots and Conserved Domains in P53 Tumour Suppressor ProteinSemantic proximity Read ↗

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.Semantic proximity Read ↗

Intrinsically disordered regions of p53 family are highly diversified in evolution.Semantic proximity Read ↗

Maximum likelihood analysis of mammalian p53 indicates the presence of positively selected sites and higher tumorigenic mutations in purifying sites.Semantic proximity Read ↗

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary ConservationSemantic proximity Read ↗

Complete Models of p53 Better Inform the Impact of Hotspot Mutations.Semantic proximity Read ↗

On the complexity measures of mutation hotspots in human TP53 protein.Semantic proximity Read ↗

Dipeptide analysis of p53 mutations and evolution of p53 family proteins.Semantic proximity Read ↗

Bioinformatic Identification of TP53 Gene Mutation Hotspots in Colorectal Cancer.Semantic proximity Read ↗

Unraveling the Structural Changes in the DNA-Binding Region of Tumor Protein p53 (TP53) upon Hotspot Mutation p53 Arg248 by Comparative Computational Approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.