Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The evolution of MDM2 family genes.

Gene - 15 Oct 2011

Momand Jamil, Villegas Alberto, Belyi Vladimir A

Abstract excerpt

MDM2 and MDM4 are proto-oncoproteins that bind to and inhibit members of the p53 protein family, p53, p73 and possibly p63. p53 is a mammalian tumor suppressor and p63 and p73 are critical for development. With the sequencing of genomes from multiple organisms there is mounting evidence for a con...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multigene Family
Share to Proto-Oncogene Proteins c-mdm2
Share to Proto-Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to Gene Duplication

Share to Genes, p53

Share to Invertebrates

Share to Vertebrates

Source

Open in PubMed Open full text

Identifiers

PMID: 21762762
DOI: 10.1016/j.gene.2011.06.030
PMCID: PMC3162079

Genes

MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21762762-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The evolution of MDM2 family genes.PMID 21762762Read ↗

Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fishSemantic proximity Read ↗

Mdm2 and p53 are highly conserved from placozoans to manSemantic proximity Read ↗

Evolution of affinity between p53 and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactionsSemantic proximity Read ↗

Mdm proteins: critical regulators of embryogenesis and homoeostasisSemantic proximity Read ↗

p53: 800 million years of evolution and 40 years of discovery.Semantic proximity Read ↗

Structure and function of MDM2 and MDM4 in health and diseaseSemantic proximity Read ↗

The role of MDM2 and MDM4 in breast cancer development and preventionSemantic proximity Read ↗

The long and the short of it: the MDM4 tail so farSemantic proximity Read ↗

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.Semantic proximity Read ↗

The regulation of MDM2 oncogene and its impact on human cancers.Semantic proximity Read ↗

Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.Semantic proximity Read ↗

MDM2 beyond cancer: podoptosis, development, inflammation, and tissue regeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.