Article

A stapled peptide inhibitor of MDM2 enables pharmacological activation of p53 in zebrafish

2026-03-30

Abstract excerpt

<h4>ABSTRACT</h4> Measuring the activity of the tumor suppressor p53 in living systems is essential for understanding its dysregulation in cancer and other conditions, such as aging and diabetes. Zebrafish ( Danio rerio ) are a powerful vertebrate model that enable such studies, due to the evolutionary conservation of p53 structure and function. However, p53 activity in zebrafish has mainly been assessed using p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7c5bc36-9b99-5ad9-ad54-8e4c58783fbe
DOI: 10.64898/2026.03.26.714438

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A stapled peptide inhibitor of MDM2 enables pharmacological activation of p53 in zebrafishDOI 10.64898/2026.03.26.714438Read

Targeting the p53–MDM2 interaction to treat cancerSemantic proximity Read

Peptide and protein chemistry approaches to study the tumor suppressor protein p53.Semantic proximity Read

Patented inhibitors of p53–Mdm2 interaction (2006 – 2008)Semantic proximity Read

Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell DeathSemantic proximity Read

Targeting the MDM2 ‐ MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancerSemantic proximity Read

Chemical Variations on the p53 Reactivation ThemeSemantic proximity Read

Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011 – present)Semantic proximity Read

Small Molecule Inhibitors of the p53-MDM2Semantic proximity Read

Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) AntagonistsSemantic proximity Read

Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trialsSemantic proximity Read

Clinical Overview of MDM2/X-Targeted TherapiesSemantic proximity Read

Targeting p53-MDM2 Interaction Using Small Molecule Inhibitors and the Challenges Needed to be AddressedSemantic proximity Read