Article

p53motifDB: integration of genomic information and tumor suppressor p53 binding motifs

2024-09-25

Abstract excerpt

<h4>ABSTRACT</h4> The tumor suppressor gene TP53 encodes the DNA binding transcription factor p53 and is one of the most commonly mutated genes in human cancer. Tumor suppressor activity requires binding of p53 to its DNA response elements and subsequent transcriptional activation of a diverse set of target genes. Despite decades of close study, the logic underlying p53 interactions with its numerous potential g...

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Literature Corpus work: 671ceca4-87f7-5181-8598-c3846305d865
DOI: 10.1101/2024.09.24.614594

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