Article

CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis

2026-04-27

Abstract excerpt

Atherosclerosis is a chronic inflammatory disease and a leading cause of cardiovascular mortality worldwide. Disease progression is closely linked to defective efferocytosis, the impaired clearance of apoptotic cells, which drives necrotic core expansion and perpetuates arterial inflammation. Targeting the CD47-SIRPα innate immune checkpoint, a dominant “don’t-eat-me” signal, limits atherosclerosis in preclinical...

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Literature Corpus work: a7f945a1-114e-5517-b3f3-6cdefaebef7b
DOI: 10.64898/2026.04.24.720546

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