Article

Helix-to-Beta-Sheet Transition Drives Self-Assembly of Glutamate Transporter EAA1 Splice Peptides

2025-08-18

Abstract excerpt

Truncated isoforms play a critical role in understanding the structural and functional properties of membrane proteins, including glutamate transporters. Here, we molecularly characterize two helical truncated isoforms of the human glutamate transporter EAA1. Using an integrative multi-omics and computational approach, we show that these isoforms, particularly one derived from the N-terminus, do not adopt the cano...

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Identifiers and source

Literature Corpus work: 77021ded-5df5-57f9-b61b-f33ee70d1e8e
DOI: 10.1101/2025.08.13.670123

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