Article

Multimodal dynamics control activity of a glial glutamate transporter

2026-06-02

Abstract excerpt

Membrane transporters move polar solutes across lipid bilayers to regulate cellular metabolism, signaling, and drug distribution. These proteins operate via an alternating-access mechanism, cycling between extracellular-, intermediate-, and intracellular-facing conformations. The human excitatory amino acid transporter 1 (EAAT1) protects neurons from excitotoxic damage by mediating the uptake of glutamate and aspa...

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Literature Corpus work: 76b09727-0577-5b51-82b4-133200898f6c
DOI: 10.64898/2026.05.29.728845

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