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Chromatin conformation of human oral epithelium can identify orofacial cleft missing functional variants

25 Aug 2022

Abstract excerpt

Genome-wide association studies (GWASs) are the most widely used method to identify genetic risk loci associated with orofacial clefts (OFC). However, despite the increasing size of cohort, GWASs are still insufficient to detect all the heritability, suggesting there are more associations under the current stringent statistical threshold. In this study, we obtained an integrated epigenomic dataset based on the...

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PMID: 36008388
DOI: 10.1038/s41368-022-00194-0

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