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Article

Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus

6 Nov 2009

Abstract excerpt

The regulated expression of large human genes can depend on long-range interactions to establish appropriate three-dimensional structures across the locus. The cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encompasses 189 kb of genomic DNA, shows a complex pattern of expression with both spatial and temporal regulation. The flanking loci, ASZ1 and CTTNBP2, show very different...

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PMID: 19897727
DOI: 10.1073/pnas.0900946106

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