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PPP1R3G Orchestrates Tumor-Immune Crosstalk and Drives Therapeutic Vulnerability in Lung Adenocarcinoma: A Multi-Omics Exploration of Prognostic, Mechanistic, and Immunotherapeutic Insights

2025-12-16

Abstract excerpt

<title>Abstract</title> <p>Background PPP1R3G, a regulatory subunit of protein phosphatase 1, remains understudied in lung adenocarcinoma (LUAD). This study systematically investigates its prognostic significance, molecular mechanisms, and therapeutic implications. Methods Multi-omics analyses integrated bulk transcriptomics (TCGA, GEO datasets), single-cell RNA sequencing, and functional assays. Prognostic mod...

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Literature Corpus work
dfaedbb8-52e6-52bd-9bb2-35ebfdf8f132
DOI
10.21203/rs.3.rs-8127673/v1
Open publication

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PPP1R3G Orchestrates Tumor-Immune Crosstalk and Drives Therapeutic Vulnerability in Lung Adenocarcinoma: A Multi-Omics Exploration of Prognostic, Mechanistic, and Immunotherapeutic InsightsDOI 10.21203/rs.3.rs-8127673/v1
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