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Article

The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasis

21 Nov 2022

Abstract excerpt

Brain metastasis occurs in approximately 30% of patients with lung adenocarcinoma (LUAD) and is closely associated with poor prognosis, recurrence, and death. However, dynamic gene regulation and molecular mechanism driving LUAD progression remain poorly understood. In this study, we performed a comprehensive single-cell transcriptome analysis using data from normal, early stage, advanced stage, and brain...

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PMID: 36514354
DOI: 10.1016/j.omtn.2022.11.019

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