Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer

Abstract excerpt

Intraductal papillary mucinous neoplasms (IPMN) is one of the known precancerous lesions. Patients’ prognosis is aggravated as IPMN transforms into invasive Pancreatic Ductal Adenocarcinoma (PDAC). The molecular mechanisms underlying this progression lack effective experimental models and urgently need to be elaborated. We performed spatial transcriptomics (ST) on fresh tissue samples from the same patient includi...

Topics

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• Cancer Immunotherapy and Biomarkers
• Cholangiocarcinoma and Gallbladder Cancer Studies
• Esophageal Cancer Research and Treatment
• Pancreatic and Hepatic Oncology Research
• Single-cell and spatial transcriptomics
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

d85d658d-3758-5638-97d7-468895d02197

DOI

10.1101/2024.08.24.608470