Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors.

doi:10.1002/alz.70629

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Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2025

Logue Mark W, Labadorf Adam, O'Neill Nicholas K, Dickson Dennis W, Dugger Brittany N, Flanagan Margaret E, Frosch Matthew P, Gearing Marla, Jin Lee-Way, Kofler Julia, Mayeux Richard, McKee Ann, Miller Carol A, Murray Melissa E, Nelson Peter T, Perrin Richard J, Schneider Julie A, Stein Thor D, Teich Andrew F, Tobunluepop Katarnut, Troncoso Juan C, Wang Shih-Hsiu, Wang Zihan, Wolozin Benjamin, Mez Jesse, Farrer Lindsay A

Abstract excerpt

INTRODUCTION: Few African American (AA) donors have been included in post mortem Alzheimer's disease (AD) studies compared to European-ancestry (EA) individuals. METHODS: We generated transcriptome-wide bulk pre-frontal cortex (PFC) gene expression data from 125 AA donors with neuropathologically determined AD and 82 AA controls. RESULTS: Transcriptome-wide significant differential expression was observed with...

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PMID: 41059714
DOI: 10.1002/alz.70629
PMCID: PMC12505200

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