Article

Mutational spectra analysis reveals bacterial niche and transmission routes

2022-07-13

Abstract excerpt

As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells. We reasoned that similar processes must occur in bacterial lineages, potentially allowing decomposition analysis to identify disrupted DNA repair processes and niche-specific mutagen exposure. Here we reconstructed mutational spectra for 84 clade...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76df93b6-68b2-563e-809a-3df97e8b3fe6
DOI: 10.1101/2022.07.13.499881

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutational spectra analysis reveals bacterial niche and transmission routesDOI 10.1101/2022.07.13.499881Read

Mutational spectra are associated with bacterial niche.Semantic proximity Read

Mutagenesis by Microbe: the Role of the Microbiota in Shaping the Cancer Genome.Semantic proximity Read

A lung-specific mutational signature enables inference of viral and bacterial respiratory niche.Semantic proximity Read

Mutational epidemiology: achievements and expectations on enhancing our understanding of the causes of cancer.Semantic proximity Read

Somatic and germline mutational processes across the tree of lifeSemantic proximity Read

Somatic and germline mutational processes across the tree of lifeSemantic proximity Read

Mutational Signatures: From Methods to Mechanisms.Semantic proximity Read

Exploring background mutational processes to decipher cancer genetic heterogeneity.Semantic proximity Read

UV signature mutations.Semantic proximity Read

MutationalPatterns: comprehensive genome-wide analysis of mutational processes.Semantic proximity Read

Topographical archetypes of somatic mutagenesis in cancerSemantic proximity Read

Identification of novel mutational signatures in Asian oral squamous cell carcinomas associated with bacterial infectionsSemantic proximity Read