Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A lung-specific mutational signature enables inference of viral and bacterial respiratory niche.

Microbial genomics - 1 May 2023

Ruis Christopher, Peacock Thomas P, Polo Luis M, Masone Diego, Alvarez Maria Soledad, Hinrichs Angie S, Turakhia Yatish, Cheng Ye, McBroome Jakob, Corbett-Detig Russell, Parkhill Julian, Floto R Andres

Abstract excerpt

Exposure to different mutagens leaves distinct mutational patterns that can allow inference of pathogen replication niches. We therefore investigated whether SARS-CoV-2 mutational spectra might show lineage-specific differences, dependent on the dominant site(s) of replication and onwards transmission, and could therefore rapidly infer virulence of emergent variants of concern (VOCs). Through mutational spectrum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to COVID-19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 37185044
DOI: 10.1099/mgen.0.001018
PMCID: PMC10272861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A lung-specific mutational signature enables inference of viral and bacterial respiratory niche.PMID 37185044Read ↗

Mutational spectra are associated with bacterial niche.Semantic proximity Read ↗

Mutational spectra analysis reveals bacterial niche and transmission routesSemantic proximity Read ↗

Mutational spectra reveal influenza virus transmission routes and adaptationSemantic proximity Read ↗

Translational Aspects of the Human Respiratory ViromeSemantic proximity Read ↗

Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural processSemantic proximity Read ↗

Infections of the lung: a predictive, preventive and personalized perspective through the lens of evolution, the emergence of SARS-CoV-2 and its pathogenesisSemantic proximity Read ↗

SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia.Semantic proximity Read ↗

Mutational Signatures as Sensors of Environmental Exposures: Role of Smoking in COVID-19 VulnerabilitiesSemantic proximity Read ↗

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathologySemantic proximity Read ↗

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathologySemantic proximity Read ↗

Origin and evolutionary analysis of the SARS-CoV-2 Omicron variantSemantic proximity Read ↗

Smoking is associated with quantifiable differences in the human lung DNA virome and metabolomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.