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Article

A trimethoprim derivative impedes antibiotic resistance evolution.

Nature communications - 19 May 2021

Manna Madhu Sudan, Tamer Yusuf Talha, Gaszek Ilona, Poulides Nicole, Ahmed Ayesha, Wang Xiaoyu, Toprak Furkan C R, Woodard DaNae R, Koh Andrew Y, Williams Noelle S, Borek Dominika, Atilgan Ali Rana, Hulleman John D, Atilgan Canan, Tambar Uttam, Toprak Erdal

Abstract excerpt

The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory evolution experiments have identified resistance-conferring mutations in the gene encoding the TMP target, bacterial dihydrofolate reductase (DHFR), in particular mutation L28R. Here, we show that 4'-desmethyltrimethoprim...

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Identifiers

PMID: 34011959
DOI: 10.1038/s41467-021-23191-z
PMCID: PMC8134463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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