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Article

Antibiotic perseverance increases the risk of resistance development.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2023

Brandis Gerrit, Larsson Jimmy, Elf Johan

Abstract excerpt

The rise of antibiotic-resistant bacterial infections poses a global threat. Antibiotic resistance development is generally studied in batch cultures which conceals the heterogeneity in cellular responses. Using single-cell imaging, we studied the growth response of Escherichia coli to sub-inhibitory and inhibitory concentrations of nine antibiotics. We found that the heterogeneity in growth increases more than...

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Identifiers

PMID: 36595701
DOI: 10.1073/pnas.2216216120
PMCID: PMC9926169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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