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Article

Pervasive gene deregulation underlies adaptation and maladaptation in trimethoprim-resistant E. coli.

mBio - 19 Dec 2023

Vinchhi Rhea, Yelpure Chetna, Balachandran Manasvi, Matange Nishad

Abstract excerpt

IMPORTANCE: Bacteria employ a number of mechanisms to adapt to antibiotics. Mutations in transcriptional regulators alter the expression levels of genes that can change the susceptibility of bacteria to antibiotics. Two-component signaling proteins are a major class of signaling molecule used by bacteria to regulate transcription. In previous work, we found that mutations in MgrB, a feedback regulator of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38032208
DOI: 10.1128/mbio.02119-23
PMCID: PMC10746255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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