Article

Emerging Approaches to Profile Accessible Chromatin from Ffpe Sections

2024-02-23

Abstract excerpt

Nucleosomes are non-uniformly distributed across eukarytic genomes, with stretches of ‘open’ chromatin strongly associated with transcriptionally active promoters and enhancers. Understanding chromatin accessibility patterns in normal tissue and how they are altered in pathologies can provide critical insights to development and disease. With the advent of high-throughput sequencing, a variety of strategies have b...

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Literature Corpus work: d8135b8f-f9ea-5089-b92a-8dd6ed83335a
DOI: 10.20944/preprints202402.1301.v1

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