Article

TREM2 inhibits rTp47-induced inflammasome activation and pyroptosis via targeting NLRP3

2024-05-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Microglia surface receptors, particularly TREM2 (triggering receptor expressed on myeloid cells 2), play a crucial role as sensors for pathogen entry and can trigger robust immune responses. However, the specific role of TREM2 in regulating microglia's response to <italic>Treponema pallidum</italic> (<italic>T. pallidum</italic>) and its underlying functional me...

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Literature Corpus work: 76cb7efa-517a-5b5a-9290-2dcf86e28222
DOI: 10.21203/rs.3.rs-4339591/v1

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