Article

Changes to culture pH and dissolved oxygen can enhance CAR T-cell generation and differentiation.

2024-01-31

Abstract excerpt

Chimeric antigen receptor (CAR) T-cell therapy is growing clinically and commercially as a powerful new approach to treat cancer. Understanding how key culture conditions such as pH and dissolved oxygen (DO) affect CAR T-cell generation and function is important in developing better CAR-T manufacturing processes and CAR T-cell therapies for patients. We used the automated mini-bioreactor (AMBR) 15 platform to asse...

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Literature Corpus work: 1cf99203-d6ff-585a-a2da-dffa6f031bc1
DOI: 10.22541/au.170669780.02853756/v1

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