Article

High-density microbioreactor process designed for automated point-of-care manufacturing of CAR T cells

2023-04-07

Abstract excerpt

While adoptive cell therapies have revolutionized cancer immunotherapy, current autologous chimeric antigen receptor (CAR) T cell manufacturing face challenges in scaling to meet patient demands. CAR T cell production still largely rely on fed-batch, manual, open processes that lack environmental monitoring and control, whereas most perfusion-based, automated, closed-system bioreactors currently suffer from large...

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Literature Corpus work: 4fbe8790-215b-5199-9f02-9b05475077c1
DOI: 10.1101/2023.04.07.535939

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