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SGLT2 inhibition promotes glomerular repopulation by cells of renin lineage in experimental kidney disease

5 Feb 2024

Abstract excerpt

AIM: Sodium glucose co-transporter-2 (SGLT2) inhibitors stimulate renal excretion of sodium and glucose and exert renal protective effects in patients with (non-)diabetic chronic kidney disease (CKD) and may as well protect against acute kidney injury (AKI). The mechanism behind this kidney protective effect remains unclear. Juxtaglomerular cells of renin lineage (CoRL) have been demonstrated to function as...

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PMID: 38314444
DOI: 10.1111/apha.14108

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