Article
Plasma renin and prorenin and renin gene variation in patients with insulin-dependent diabetes mellitus and nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Aug 1999
Deinum J, Tarnow L, van Gool J M, de Bruin R A, Derkx F H, Schalekamp M A, Parving H H
Abstract excerpt
BACKGROUND: The most striking abnormality in the renin angiotensin system in diabetic nephropathy (DN) is increased plasma prorenin. Renin is thought to be low or normal in DN. In spite of altered (pro)renin regulation the renin gene has not been studied for contribution to the development of DN. METHODS: We studied plasma renin, prorenin, and four polymorphic markers of the renin gene in 199 patients with IDDM...
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