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Article

Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation.

Cancer discovery - 3 Jun 2025

Garcia Geyon L, Orellana Taylor, Gorecki Grace, Frisbie Leonard, Baruwal Roja, Suresh Swathi, Goldfeld Ester, Beddows Ian, MacFawn Ian P, Britt Ananya K, Hale Macy M, Elhaw Amal Taher, Isett Brian R, Hempel Nadine, Bao Riyue, Shen Hui, Buckanovich Ronald J, Finkel Toren, Drapkin Ronny, Soong T Rinda, Bruno Tullia C, Atiya Huda I, Coffman Lan G

Abstract excerpt

The fundamental steps in high-grade serous ovarian cancer (HGSOC) initiation are unclear, presenting critical barriers to the prevention and early detection of this deadly disease. Current models propose that fallopian tube epithelial (FTE) cells transform into serous tubal intraepithelial carcinoma (STIC) precursor lesions and subsequently into HGSOC. In this study, we report that an epigenetically altered...

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Identifiers

PMID: 40084985
DOI: 10.1158/2159-8290.CD-24-0805
PMCID: PMC12130807

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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