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Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

2024-05-28

Abstract excerpt

The fundamental steps in high-grade serous ovarian cancer (HGSOC) initiation are unclear, thus providing critical barriers to the development of prevention or early detection strategies for this deadly disease. Increasing evidence demonstrates most HGSOC starts in the fallopian tube epithelium (FTE). Current models propose HGSOC initiates when FTE cells acquire increasing numbers of mutations allowing cells to evo...

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Identifiers and source

Literature Corpus work
2ee686f3-0ed2-5418-a0fd-13280a02e7a6
DOI
10.1101/2024.05.23.595550
Open publication

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Stromal mediated DNA damage promotes high grade serous ovarian cancer initiationDOI 10.1101/2024.05.23.595550
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