Article

Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis

2023-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Seventy percent of patients with late-stage breast cancer develop distal bone metastases; however, the mechanism by which the metabolic microenvironment affects resistance to therapy remains unknown. We investigated the metabolic bone microenvironment and identified glutathione metabolism as the top pathway in osteoclasts, which provides feedback to tumor cells to help neutralize oxidative stres...

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Literature Corpus work: 7670bcc7-b34a-5e04-b722-33dad981ab44
DOI: 10.1101/2023.08.15.553338

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