Article

Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress response

2025-04-26

Abstract excerpt

<h4>Background</h4> Metabolic and stress response adaptations in prostate cancer (PCa) mediate tumor resistance to radiation therapy (RT). Our study investigated the roles of glutamine (Gln) transporters SLC1A5, SLC7A5 , and SLC38A1 in regulating NUPR1 -mediated stress response, PCa cell survival, metabolic reprogramming, and response to RT. <h4>Methods</h4> The radiosensitizing potential of GLS inhibition w...

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Literature Corpus work: 8adc1cbc-a412-5016-ba20-b2f5034c338b
DOI: 10.1101/2025.04.22.650063

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