Article

Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors

2020-04-08

Abstract excerpt

Redox cofactor production is integral towards antioxidant generation, clearance of reactive oxygen species, and overall tumor response to ionizing radiation treatment. To identify systems-level alterations in redox metabolism which confer resistance to radiation therapy, we developed a bioinformatics pipeline for integrating multi-omics data into personalized genome-scale flux balance analysis models of 716 radiat...

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Literature Corpus work: 95ca1fb0-a39a-5b2b-ab26-c656670c35f4
DOI: 10.1101/2020.04.07.029694

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