Article
Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer.
British journal of cancer - 1 Mar 2022
Jaggupilli Appalaraju, Ly Stanley, Nguyen Khoa, Anand Vivek, Yuan Bin, El-Dana Fouad, Yan Yuanqing, Arvanitis Zoe, Piyarathna Danthasinghe Waduge Badrajee, Putluri Nagireddy, Piwnica-Worms Helen, Manning Henry Charles, Andreeff Michael, Battula V Lokesh
Abstract excerpt
BACKGROUND: Metabolic stress resulting from nutrient deficiency is one of the hallmarks of a growing tumour. Here, we tested the hypothesis that metabolic stress induces breast cancer stem-like cell (BCSC) phenotype in triple-negative breast cancer (TNBC). METHODS: Flow cytometry for GD2 expression, mass spectrometry and Ingenuity Pathway Analysis for metabolomics, bioinformatics, in vitro tumorigenesis and in...
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