Article

Longitudinal cancer evolution from single cells

2020-01-15

Abstract excerpt

<h4>ABSTRACT</h4> The rise of longitudinal single-cell sequencing experiments on patient-derived cell cultures, xenografts and organoids is opening new opportunities to track cancer evolution in single tumors and to investigate intra-tumor heterogeneity. This is particularly relevant when assessing the efficacy of therapies over time on the clonal composition of a tumor and in the identification of resistant subc...

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Literature Corpus work: 108395b2-d617-5e36-bc54-9fd06a347ad6
DOI: 10.1101/2020.01.14.906453

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