Article

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8 <sup>+</sup> Dendritic Cells

2018-07-23

Abstract excerpt

Apoptotic cell death of Dendritic cells (DCs) is critical for immune homeostasis. Although intrinsic mechanisms controlling DC death have not been fully characterized up to now, experimentally enforced inhibition of DC-death causes various autoimmune diseases in model systems. We have generated mice deficient for Protein Phosphatase with EF-Hands 2 (Ppef2), which is selectively expressed in CD8 + DCs, but not in...

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Literature Corpus work: 7650a320-91f6-5c98-ac9f-78f35fe72345
DOI: 10.1101/374652

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