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Article

Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells

10 May 2013

Abstract excerpt

Humans and mice with impaired perforin-dependent cytotoxic function may develop excessive T-cell activation and the fatal disorder hemophagocytic lymphohistiocytosis (HLH) after infection. Though cytotoxic lymphocytes can kill antigen-presenting cells, the physiological mechanism of perforin-mediated immune regulation has never been demonstrated in a disease-relevant context. We used a murine model of HLH to...

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PMID: 23660960
DOI: 10.1182/blood-2013-04-495309

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