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Article

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.

Nature cell biology - 1 Jun 2017

Tavernier Simon J, Osorio Fabiola, Vandersarren Lana, Vetters Jessica, Vanlangenakker Nele, Van Isterdael Gert, Vergote Karl, De Rycke Riet, Parthoens Eef, van de Laar Lianne, Iwawaki Takao, Del Valle Juan R, Hu Chih-Chi Andrew, Lambrecht Bart N, Janssens Sophie

Abstract excerpt

The IRE1-XBP1 signalling pathway is part of a cellular programme that protects against endoplasmic reticulum (ER) stress, but also controls development and survival of immune cells. Loss of XBP1 in splenic type 1 conventional dendritic cells (cDC1s) results in functional alterations without affecting cell survival. However, in mucosal cDC1s, loss of XBP1 impaired survival in a tissue-specific manner-while lung...

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Identifiers

PMID: 28459443
DOI: 10.1038/ncb3518
PMCID: PMC5563826

Genes

XBP1
ATF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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