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Article

CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators.

Experimental neurology - 1 Sept 2022

Hörner Michaela, Groh Janos, Klein Dennis, Ilg Winfried, Schöls Ludger, Dos Santos Sara, Bergmann Anna, Klebe Stephan, Cauhape Margaux, Branchu Julien, El Hachimi Khalid Hamid, Stevanin Giovanni, Darios Frédéric, Martini Rudolf

Abstract excerpt

Pharmacological targeting of neuroinflammation in distinct models of genetically mediated disorders of the central nervous system (CNS) has been shown to attenuate disease outcome significantly. These include mouse models mimicking distinct subtypes of neuronal ceroid lipofuscinoses (NCL, CLN diseases) as well as hereditary spastic paraplegia type 2 (HSP/SPG2). We here show in a model of another, complicated HSP...

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Identifiers

PMID: 35605667
DOI: 10.1016/j.expneurol.2022.114119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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