Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients.

doi:10.1007/s00401-023-02675-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients.

Acta neuropathologica - 2 Feb 2024

Krumm Laura, Pozner Tatyana, Zagha Naime, Coras Roland, Arnold Philipp, Tsaktanis Thanos, Scherpelz Kathryn, Davis Marie Y, Kaindl Johanna, Stolzer Iris, Süß Patrick, Khundadze Mukhran, Hübner Christian A, Riemenschneider Markus J, Baets Jonathan, Günther Claudia, Jayadev Suman, Rothhammer Veit, Krach Florian, Winkler Jürgen, Winner Beate, Regensburger Martin

Abstract excerpt

Biallelic loss of SPG11 function constitutes the most frequent cause of complicated autosomal recessive hereditary spastic paraplegia (HSP) with thin corpus callosum, resulting in progressive multisystem neurodegeneration. While the impact of neuroinflammation is an emerging and potentially treatable aspect in neurodegenerative diseases and leukodystrophies, the role of immune cells in SPG11-HSP patients is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hereditary Neurological Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice

Share to Mutation

Share to Neuroinflammatory Diseases

Share to Neurons

Share to Proteins

Share to RNA regulation and disease

Share to Spastic Paraplegia, Hereditary

Source

Open in PubMed Open full text

Identifiers

PMID: 38305941
DOI: 10.1007/s00401-023-02675-w
PMCID: PMC10837238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients.PMID 38305941Read ↗

Disease-associated microglia and activation of CD8 <sup>+</sup> T cells precede neuronal cell loss in a model of hereditary spastic paraplegiaSemantic proximity Read ↗

CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators.Semantic proximity Read ↗

Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration.Semantic proximity Read ↗

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopmentSemantic proximity Read ↗

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease.Semantic proximity Read ↗

Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i> -ALS iPSC-derived microglia contributes to neurodegenerationSemantic proximity Read ↗

GSK3ß‐dependent dysregulation of neurodevelopment in SPG11‐patient induced pluripotent stem cell modelSemantic proximity Read ↗

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegenerationSemantic proximity Read ↗

An adapted stem cell-derived microglia protocol for the study of microgliopathies and other neurological disordersSemantic proximity Read ↗

Neurological Phenotypes of SOCS1 Haploinsufficiency: Insights from Functional and Histological Investigations.Semantic proximity Read ↗

Aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia.Semantic proximity Read ↗

Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.