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Genomic imprinting of the metabolic regulator gene <i>Klf14</i> is regulated by a paternal sub-TAD anchored at <i>Mest</i> and a shared enhancer in mice

2026-05-13

Abstract excerpt

KLF14 acts as a master regulator of gene expression in adipose tissue and variants at the human KLF14 gene show strong and reproducible association with type 2 diabetes and metabolic syndrome. Risk alleles are only pathologic when maternally inherited, consistent with the observation that KLF14/Klf14 is a maternally-expressed imprinted gene in human and mouse. However, how genomic imprinting is regulated at this...

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Literature Corpus work
76347bb8-31aa-5a13-b0a4-6877ea274701
DOI
10.64898/2026.05.09.724006
Open publication

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Genomic imprinting of the metabolic regulator gene <i>Klf14</i> is regulated by a paternal sub-TAD anchored at <i>Mest</i> and a shared enhancer in miceDOI 10.64898/2026.05.09.724006
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