Article
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.
Nature genetics - 1 Jun 2011
Small Kerrin S, Hedman Asa K, Grundberg Elin, Nica Alexandra C, Thorleifsson Gudmar, Kong Augustine, Thorsteindottir Unnur, Shin So-Youn, Richards Hannah B, Soranzo Nicole, Ahmadi Kourosh R, Lindgren Cecilia M, Stefansson Kari, Dermitzakis Emmanouil T, Deloukas Panos, Spector Timothy D, McCarthy Mark I
Abstract excerpt
Genome-wide association studies have identified many genetic variants associated with complex traits. However, at only a minority of loci have the molecular mechanisms mediating these associations been characterized. In parallel, whereas cis regulatory patterns of gene expression have been extensively explored, the identification of trans regulatory effects in humans has attracted less attention. Here we show...
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