Article
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Nature genetics - 1 Apr 2018
Small Kerrin S, Todorčević Marijana, Civelek Mete, El-Sayed Moustafa Julia S, Wang Xiao, Simon Michelle M, Fernandez-Tajes Juan, Mahajan Anubha, Horikoshi Momoko, Hugill Alison, Glastonbury Craig A, Quaye Lydia, Neville Matt J, Sethi Siddharth, Yon Marianne, Pan Calvin, Che Nam, Viñuela Ana, Tsai Pei-Chien, Nag Abhishek, Buil Alfonso, Thorleifsson Gudmar, Raghavan Avanthi, Ding Qiurong, Morris Andrew P, Bell Jordana T, Thorsteinsdottir Unnur, Stefansson Kari, Laakso Markku, Dahlman Ingrid, Arner Peter, Gloyn Anna L, Musunuru Kiran, Lusis Aldons J, Cox Roger D, Karpe Fredrik, McCarthy Mark I
Abstract excerpt
Individual risk of type 2 diabetes (T2D) is modified by perturbations to the mass, distribution and function of adipose tissue. To investigate the mechanisms underlying these associations, we explored the molecular, cellular and whole-body effects of T2D-associated alleles near KLF14. We show that KLF14 diabetes-risk alleles act in adipose tissue to reduce KLF14 expression and modulate, in trans, the expression...
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