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A maternal-effect <i>Padi6</i> variant results in abnormal nuclear localization of DNMT1 and failure of epigenetic reprogramming and zygotic genome activation in mouse embryos

2023-10-10

Abstract excerpt

PADI6 belongs to the multi-protein sub-cortical maternal complex (SCMC) that is present specifically in mammalian oocytes and early embryos. Maternal inactivation of SCMC genes generally results in early embryo lethality. In humans, variants in a subset of SCMC genes have been found in the healthy mothers of children affected by genomic imprinting disorders and characterized by multi-locus imprinting disturbances...

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Literature Corpus work
2c7530fd-7b7b-5122-b2b4-0ea56974ffee
DOI
10.1101/2023.10.09.561545
Open publication

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A maternal-effect <i>Padi6</i> variant results in abnormal nuclear localization of DNMT1 and failure of epigenetic reprogramming and zygotic genome activation in mouse embryosDOI 10.1101/2023.10.09.561545
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