Article

Restraint of Powassan virus replication by TRIM5α facilitates viral avoidance of antiviral immunity

2026-03-16

Abstract excerpt

TRIpartite Motif (TRIM) protein 5 alpha (TRIM5α) is a well characterized cellular inhibitor of lentivirus replication that limits transmission of related viruses between primates. We previously reported that TRIM5α derived from humans and rhesus macaques inhibits replication of orthoflaviviruses belonging to the tick-borne encephalitis virus (TBEV) serocomplex, including TBEV, Kyasanur forest disease virus and Lan...

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Literature Corpus work: 760bfc24-c95b-5d3f-b62b-f8c641c6e89c
DOI: 10.64898/2026.03.15.711935

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