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Article

Restriction of an Extinct Retrovirus by the Human TRIM5α Antiviral Protein

21 Jun 2007

Abstract excerpt

Primate genomes contain a large number of endogenous retroviruses and encode evolutionarily dynamic proteins that provide intrinsic immunity to retroviral infections. We report here the resurrection of the core protein of a 4-million-year-old endogenous virus from the chimpanzee genome and show that the human variant of the intrinsic immune protein TRIM5alpha can actively prevent infection by this virus. However,...

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Identifiers

PMID: 17588933
DOI: 10.1126/science.1140579

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