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Article

Activation of p53 Facilitates the Target Search in DNA by Enhancing the Target Recognition Probability.

Journal of molecular biology - 17 Jul 2016

Itoh Yuji, Murata Agato, Sakamoto Seiji, Nanatani Kei, Wada Takehiko, Takahashi Satoshi, Kamagata Kiyoto

Abstract excerpt

Tumor suppressor p53 binds to the target in a genome and regulates the expression of downstream genes. p53 searches for the target by combining three-dimensional diffusion and one-dimensional sliding along the DNA. To examine the regulation mechanism of the target binding, we constructed the pseudo-wild type (pseudo-WT), activated (S392E), and inactive (R248Q) mutants of p53 and observed their target binding in...

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Identifiers

PMID: 27291286
DOI: 10.1016/j.jmb.2016.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of p53 Facilitates the Target Search in DNA by Enhancing the Target Recognition Probability.PMID 27291286Read ↗

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Unraveling the Allosteric Mechanism of Four Cancer-related Mutations in the Disruption of p53-DNA Interaction.Semantic proximity Read ↗

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