Article
How do Hox transcription factors find their target genes in the nucleus of living cells?
Biologie aujourd'hui - 1 Jan 2011
Gehring Walter J
Abstract excerpt
Homeotic mutations first found in Drosophila led to the identification of Hox genes in all bilateria. These genes are exceptional in that they are arranged in an ordered cluster, in which they are positioned in the same order along the chromosome as they are expressed along the antero-posterior axis to specify the corresponding body regions. They share a highly conserved DNA sequence of 180 bp, the homeobox which...
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